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The epidermal growth factor receptor (EGF-R) is a protein that has been intensely studied for a number of years. It was one of the first receptors described to stimulate cells when growth factors were discovered and has been extensively characterized. The EGFR is a single transmembrane protein with intrinsic kinase activity, and ligand-induced homo- or hetero-oligomerization is believed to be a key step in its activation. We have produced monoclonal antibodies against the EGF-R, and used these to investigate the cellular distribution of the EGF-R. In human cancer cells, monoclonal antibodies against the EGF-R were able to block the EGF-induced stimulation of growth in soft agar and tumor formation in nude mice. These results provide strong evidence for the importance of EGF-R oligomerization in the control of cell growth.This week the BBC Radio 4 have been running a series on the history of cider called "Cider Cider Cider". To coincide with the programme there's been a new, well overdue, official cider history on the BBC website which includes a history of the press and casks, cider-making technology, and the role of cider in the Industrial Revolution. The piece is written by a famous cider maker, and includes interviews with cidermakers, and those who know about cider, from David Hamilton, Chief Executive of the Cider Institute, to the cider director of the pub chain Greene King. The cider press was patented in Germany in 1231, and a press was used by the monks in Saxony, Germany, in the early Middle Ages for making apple cider. At about the same time that the Saxons used a type of cider press called a pannage press, the English started using a sort of cider mill that was called a dingle or two creeper. The dingle or two creeper was made up of a wooden cradle suspended by a pivoting arm, set above a drain. 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